Feasibility, Safety, and Therapeutic Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets in a Porcine Ischemic Cardiomyopathy Model

Kawamura, Masashi; Miyagawa, Shigeru; Miki, Kenji; Saito, Atsuhiro; Fukushima, Satsuki; Higuchi, Takahiro; Kawamura, Takuji; Kurata, Mie; Daimon, Takashi; Shimizu, Tatsuya; Okano, Teruo; Sawa, Yoshiki

doi:10.1161/circulationaha.111.084343

Public

Feasibility, Safety, and Therapeutic Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets in a Porcine Ischemic Cardiomyopathy Model

Published in Circulation • Sep 10, 2012

Authors:

Masashi Kawamura

Shigeru Miyagawa

Kenji Miki

Abstract

BACKGROUND: Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are a promising source of cells for regenerating myocardium. However, several issues, especially the large-scale preparation of hiPS-CMs and elimination of undifferentiated iPS cells, must be resolved before hiPS cells...

Subject

Medicine

Transplantation

Induced pluripotent stem cell

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