Variations in the<i>NRAMP1</i>Gene and Susceptibility to Tuberculosis in West Africans

Bellamy, Richard; Ruwende, Cyril; Corrah, Tumani; McAdam, Keith; Whittle, Hilton; V. S. Hill, Adrian

doi:10.1056/nejm199803053381002

Public

Variations in theNRAMP1Gene and Susceptibility to Tuberculosis in West Africans

Published in New England Journal of Medicine • Mar 5, 1998

Authors:

Richard Bellamy

Cyril Ruwende

Tumani Corrah

Abstract

BACKGROUND: Genetic factors may affect the susceptibility to tuberculosis, but no specific genes governing susceptibility have been identified. In mice, natural resistance to infection with some mycobacteria is influenced by the gene for natural-resistance-associated macrophage protein 1 (Nramp1), b...

Subject

Tuberculosis

Genotype

Odds ratio

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