Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice

P. Lindberg, Frederik; C. Bullard, Daniel; E. Caver, Tony; D. Gresham, Hattie; L. Beaudet, Arthur; J. Brown, Eric

doi:10.1126/science.274.5288.795

Public

Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice

Shared by NobleBlocks on Nov 1, 1996 • 12:00 AM UTC

Authors:

Frederik P. Lindberg

Daniel C. Bullard

Tony E. Caver

Abstract

Granulocyte [polymorphonuclear leucocyte (PMN)] migration to sites of infection and subsequent activation is essential for host defense. Gene-targeted mice deficient for integrin-associated protein (IAP, also termed CD47) succumbed to Escherichia coli peritonitis at inoccula survived by heterozygous...

Discussions