Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency

S. Knisely, A.; Strautnieks, Sandra; Meier, Yvonne; Stieger, Bruno; A. Byrne, Jane; Portmann, Bernard; N. Bull, Laura; Pawlikowska, Ludmila; Bilezikçi, Banu; Özçay, Figen; László, Aranka; Tiszlavicz, László; Moore, Lynette; Raftos, Jeremy; Arnell, Henrik; Fischler, Björn; Németh, Antal; Papadogiannakis, Nikos; Cielecka–Kuszyk, Joanna; Jankowska, Irena; Pawłowska, Joanna; Melín‐Aldana, Héctor; M. Emerick, Karan; F. Whitington, Peter; Mieli‐Vergani, Giorgina; J. Thompson, Richard

doi:10.1002/hep.21287

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Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency

Published in Hepatology • Jul 26, 2006

Authors:

A. S. Knisely

Sandra Strautnieks

Yvonne Meier

Abstract

Hepatocellular carcinoma (HCC) is rare in young children. We attempted to see if immunohistochemical and mutational-analysis studies could demonstrate that deficiency of the canalicular bile acid transporter bile salt export pump (BSEP) and mutation in ABCB11, encoding BSEP, underlay progressive fam...

Subject

Hepatocellular carcinoma

Bile Salt Export Pump

Gastroenterology

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