A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

R. Rosenfeld, Myrna; Ye, Xiaobu; G. Supko, Jeffrey; Desideri, Serena; A. Grossman, Stuart; Brem, Steven; Mikkelson, Tom; Wang, Daniel; C Chang, Yunyoung; Hu, Janice; McAfee, Quentin; Fisher, Joy; B. Troxel, Andrea; Piao, Shengfu; F. Heitjan, Daniel; Tan, Kay-See; Pontiggia, Laura; J. O’Dwyer, Peter; E. Davis, Lisa; K. Amaravadi, Ravi

doi:10.4161/auto.28984

Public

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

Published in Autophagy • May 20, 2014

Authors:

Myrna R. Rosenfeld

Xiaobu Ye

Jeffrey G. Supko

Abstract

Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose (MTD) and efficacy of HCQ in combination with radiation therapy (RT) and temozolomide (TMZ...

Subject

Temozolomide

Hydroxychloroquine

Medicine

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