A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in <i>Drosophila</i>

Gunawardane, Lalith; Saito, Kuniaki; M. Nishida, Kazumichi; Miyoshi, Keita; Kawamura, Yoshinori; Nagami, Tomoko; Siomi, Haruhiko; C. Siomi, Mikiko

doi:10.1126/science.1140494

Public

A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila

Published in Science • Feb 23, 2007

Authors:

Lalith Gunawardane

Kuniaki Saito

Kazumichi M. Nishida

Abstract

In Drosophila, repeat-associated small interfering RNAs (rasiRNAs) are produced in the germ line by a Dicer-independent pathway and function through the PIWI subfamily of Argonautes to ensure silencing of retrotransposons. We sequenced small RNAs associated with the PIWI subfamily member AGO3. Altho...

Subject

Piwi-interacting RNA

Retrotransposon

Biology

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