Alignment and Sensitive Detection of DNA by a Moving Interface

Bensimon, A.; Simon, A.; Chiffaudel, A.; Croquette, V.; Heslot, F.; Bensimon, D.

doi:10.1126/science.7522347

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Alignment and Sensitive Detection of DNA by a Moving Interface

Shared by NobleBlocks on Sep 28, 1994 • 12:00 AM UTC

Authors:

A. Bensimon

A. Simon

A. Chiffaudel

Abstract

In a process called "molecular combing," DNA molecules attached at one end to a solid surface were extended and aligned by a receding air-water interface and left to dry on the surface. Molecular combing was observed to extend the length of the bacteriophage λ DNA molecule to 21.5 ± 0.5 micrometers ...

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