RNA Silencing of Mcl-1 Enhances ABT-737-Mediated Apoptosis in Melanoma: Role for a Caspase-8-Dependent Pathway

M. Keuling, Angela; Felton, Kathleen; Parker, Arabesque; Akbari, Majid; E. Andrew, Susan; A. Tron, Victor

doi:10.1371/journal.pone.0006651

Public

RNA Silencing of Mcl-1 Enhances ABT-737-Mediated Apoptosis in Melanoma: Role for a Caspase-8-Dependent Pathway

Published in PLoS ONE • Aug 14, 2009

Authors:

Angela M. Keuling

Kathleen Felton

Arabesque Parker

Abstract

BACKGROUND: Malignant melanoma is resistant to almost all conventional forms of chemotherapy. Recent evidence suggests that anti-apoptotic proteins of the Bcl-2 family are overexpressed in melanoma and may contribute to melanoma's striking resistance to apoptosis. ABT-737, a small-molecule inhibitor...

Subject

Melanoma

Apoptosis

Cancer research

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