Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure

M. Kocher, Hemant; Steward, M; Leather, Andrew; Cullen, Paul

doi:10.1046/j.0007-1323.2001.02042.x

Public

Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure

Published in British journal of surgery • Apr 1, 2002

Authors:

Hemant M. Kocher

M Steward

Andrew Leather

Abstract

INTRODUCTION: Glyceryl trinitrate (GTN) ointment (0 small middle dot2 per cent) has an efficacy of up to 68 per cent in healing chronic anal fissure, but with headache as a major side-effect. Diltiazem hydrochloride (DTZ) cream (2 per cent) is expected to have fewer side-effects. METHODS: A prospect...

Subject

Medicine

Anal fissure

Randomized controlled trial

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