t‐[3H]Butylbicycloorthobenzoate: New Radioligand Probe for the γ‐Aminobutyric Acid–Regulated Chloride Ionophore

J. Lawrence, Lowell; Palmer, Christopher; W. Gee, Kelvin; Wang, Xiaoyu; I. Yamamura, Henry; E. Casida, John

doi:10.1111/j.1471-4159.1985.tb04063.x

Public

t‐[3H]Butylbicycloorthobenzoate: New Radioligand Probe for the γ‐Aminobutyric Acid–Regulated Chloride Ionophore

Published in Journal of Neurochemistry • Sep 1, 1985

Authors:

Lowell J. Lawrence

Christopher Palmer

Kelvin W. Gee

Abstract

t-[3H]Butylbicycloorthobenzoate [( 3H]TBOB; 22 Ci/mmol) was prepared by reductive dechlorination of its 4-chlorophenyl analog with tritium gas. This new radioligand binds reversibly to fresh washed rat brain P2 membranes in 500 mM NaCl plus 50 mM sodium-potassium phosphate buffer (pH 7.4) at 25 degr...

Subject

Radioligand

Ionophore

Chemistry

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