Two d-2-Hydroxy-acid Dehydrogenases in Arabidopsis thaliana with Catalytic Capacities to Participate in the Last Reactions of the Methylglyoxal and β-Oxidation Pathways

K. M. Engqvist, Martin; F. Drincovich, Marı́a; Flügge, Ulf‐Ingo; G. Maurino, Verónica

doi:10.1074/jbc.m109.021253

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Two d-2-Hydroxy-acid Dehydrogenases in Arabidopsis thaliana with Catalytic Capacities to Participate in the Last Reactions of the Methylglyoxal and β-Oxidation Pathways

Published in Journal of Biological Chemistry • Jul 9, 2009

Authors:

Martin K. M. Engqvist

Marı́a F. Drincovich

Ulf‐Ingo Flügge

Abstract

The Arabidopsis thaliana locus At5g06580 encodes an ortholog to Saccharomyces cerevisiae d-lactate dehydrogenase (AtD-LDH). The recombinant protein is a homodimer of 59-kDa subunits with one FAD per monomer. A substrate screen indicated that AtD-LDH catalyzes the oxidation of d- and l-lactate, d-2-h...

Subject

Methylglyoxal

Biochemistry

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