Ionic Mechanisms of Neuronal Excitation by Inhibitory GABA <sub>A</sub> Receptors

J. Staley, Kevin; L. Soldo, Brandi; R. Proctor, William

doi:10.1126/science.7638623

Public

Ionic Mechanisms of Neuronal Excitation by Inhibitory GABA A Receptors

Published in Science • Aug 18, 1995

Authors:

Kevin J. Staley

Brandi L. Soldo

William R. Proctor

Abstract

Gamma-aminobutyric acid A (GABAA) receptors are the principal mediators of synaptic inhibition, and yet when intensely activated, dendritic GABAA receptors excite rather than inhibit neurons. The membrane depolarization mediated by GABAA receptors is a result of the differential, activity-dependent ...

Subject

GABAA receptor

Inhibitory postsynaptic potential

Depolarization

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