Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

Jin, Jing-Ji; Kim, Hong-Duck; Maxwell, Jill; Li, Ling; Fukuchi, Ken‐ichiro

doi:10.1186/1742-2094-5-23

Public

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

Published in Journal of Neuroinflammation • May 29, 2008

Authors:

Jing-Ji Jin

Hong-Duck Kim

Jill Maxwell

Abstract

BACKGROUND: Abeta deposits in the brains of patients with Alzheimer's disease (AD) are closely associated with innate immune responses such as activated microglia and increased cytokines. Accumulating evidence supports the hypothesis that innate immune/inflammatory responses play a pivotal role in t...

Subject

Microglia

Innate immune system

Chemokine

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