Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

Krüger, Bernd; Krick, Stefanie; Dhillon, Navdeep; Lerner, Susan; Ames, Scott; S. Bromberg, Jonathan; Lin, Marvin; Walsh, Liron; P. Vella, John; Fischereder, Michael; K. Krämer, Bernhard; B. Colvin, Robert; S. Heeger, Peter; Murphy, Barbara; Schröppel, Bernd

doi:10.1073/pnas.0810169106

Public

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

Published in Proceedings of the National Academy of Sciences • Feb 14, 2009

Authors:

Bernd Krüger

Stefanie Krick

Navdeep Dhillon

Abstract

While studies in animal models have linked Toll-like receptor (TLR) 4 signaling to kidney injury induced by ischemia and reperfusion, the relevance of TLR4 activation to allograft injury in human kidney transplants is unknown. Here we show that TLR4 is constitutively expressed within all donor kidne...

Subject

TLR4

HMGB1

Proinflammatory cytokine

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