Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia

Chalandon, Yves; Thomas, Xavier; Hayette, Sandrine; Cayuela, Jean‐Michel; Abbal, Claire; Huguet, Françoise; Raffoux, Emmanuel; Leguay, Thibaut; Rousselot, Philippe; Leprêtre, Stéphane; Escoffre‐Barbe, Martine; Maury, Sébastien; Berthon, Céline; Tavernier, Emmanuelle; Lambert, Jean‐François; Lafage‐Pochitaloff, Mårina; Lhéritier, Véronique; Chevret, Sylvie; Ifrah, Norbert; Dombret, Hervé

doi:10.1182/blood-2015-02-627935

Public

Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia

Published in Blood • Apr 16, 2015

Authors:

Yves Chalandon

Xavier Thomas

Sandrine Hayette

Abstract

In this study, we randomly compared high doses of the tyrosine kinase inhibitor imatinib combined with reduced-intensity chemotherapy (arm A) to standard imatinib/hyperCVAD (cyclophosphamide/vincristine/doxorubicin/dexamethasone) therapy (arm B) in 268 adults (median age, 47 years) with Philadelphia...

Subject

Imatinib

Medicine

Lymphoblastic Leukemia

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