Estrogen Action Via the G Protein-Coupled Receptor, GPR30: Stimulation of Adenylyl Cyclase and cAMP-Mediated Attenuation of the Epidermal Growth Factor Receptor-to-MAPK Signaling Axis

J. Filardo, Edward; A. Quinn, Jeffrey; Raymond Frackelton, A.; I. Bland, Kirby

doi:10.1210/mend.16.1.0758

Public

Estrogen Action Via the G Protein-Coupled Receptor, GPR30: Stimulation of Adenylyl Cyclase and cAMP-Mediated Attenuation of the Epidermal Growth Factor Receptor-to-MAPK Signaling Axis

Published in Molecular Endocrinology • Jan 1, 2002

Authors:

Edward J. Filardo

Jeffrey A. Quinn

A. Raymond Frackelton

Abstract

Estrogen triggers rapid yet transient activation of the MAPKs, extracellular signal-regulated kinase (Erk)-1 and Erk-2. We have reported that this estrogen action requires the G protein-coupled receptor, GPR30, and occurs via Gbetagamma-subunit protein-dependent transactivation of the epidermal grow...

Subject

MAPK/ERK pathway

GPER

Adenylyl cyclase

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