Mildly oxidized low density lipoprotein rapidly stimulates via activation of the lysophosphatidic acid receptor Src family and Syk tyrosine kinases and Ca2+ influx in human platelets.

P, Maschberger; M, Bauer; J, Baumann-Siemons; KJ, Zangl; EV, Negrescu; AJ, Reininger; W, Siess

doi:10.1074/jbc.m910257199

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Mildly oxidized low density lipoprotein rapidly stimulates via activation of the lysophosphatidic acid receptor Src family and Syk tyrosine kinases and Ca2+ influx in human platelets.

Shared by NobleBlocks on Jun 1, 2000 • 12:00 AM UTC

Authors:

Maschberger P

Bauer M

Baumann-Siemons J

Abstract

In contrast to native low density lipoprotein (LDL), mildly oxidized LDL (mox-LDL) induced platelet shape change and stimulated during shape change the tyrosine phosphorylation of specific proteins including Syk; the translocation of Src, Fyn, and Syk to the cytoskeleton; and the increase of cytosol...

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