Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families: the α-, β-, γ-, δ-, and ζ-CAs The α- β- and δ-CAs contain a Zn(II) ion at the active site, the γ-CAs are probably Fe(II) enzymes (... View More