Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy

Bursch, Wilfried; Ellinger, Adolf; Kienzl, Harald; Török, Ladislaus; Pandey, Siyaram; Sikorska, Marianna; Walker, Roy; Hermann, R.

doi:10.1093/carcin/17.8.1595

Public

Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy

Published in Carcinogenesis • Jan 1, 1996

Authors:

Wilfried Bursch

Adolf Ellinger

Harald Kienzl

Abstract

Active cell death in hormone-dependent cells was studied using cultured human mammary carcinoma cells (MCF-7) treated with the anti-estrogens (AEs) tamoxifen (TAM), 4-hydroxy-tamoxifen (OH-TAM) or ICI 164 384 (10(-8)-10(-5) M) as a model. The following results were obtained. (i) In untreated MCF-7 c...

Subject

Programmed cell death

Apoptosis

Fragmentation (computing)

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