Midazolam Hydroxylation by Human Liver Microsomes<i>In Vitro</i>: Inhibition by Fluoxetine, Norfluoxetine, and by Azole Antifungal Agents

L. von Moltke, Lisa; J. Greenblatt, David; Schmider, Jürgen; Duan, Su; Wright, Caroline; S. Harmatz, Jerold; I. Shader, Richard

doi:10.1002/j.1552-4604.1996.tb04251.x

Public

Midazolam Hydroxylation by Human Liver MicrosomesIn Vitro: Inhibition by Fluoxetine, Norfluoxetine, and by Azole Antifungal Agents

Published in The Journal of Clinical Pharmacology • Sep 1, 1996

Authors:

Lisa L. von Moltke

David J. Greenblatt

Jürgen Schmider

Abstract

Biotransformation of the imidazobenzodiazepine midazolam to its alpha-hydroxy and 4-hydroxy metabolites was studied in vitro using human liver microsomal preparations. Formation of alpha-hydroxy-midazolam was a high-affinity (Km = 3.3 mumol/L) Michaelis-Menten process coupled with substrate inhibiti...

Subject

Ketoconazole

Midazolam

Metabolite

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!