Plastin3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial–Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis

Yokobori, Takehiko; Iinuma, Hisae; Shimamura, Teppei; Imoto, Seiya; Sugimachi, Keishi; Ishii, Hideshi; Iwatsuki, Masaaki; Ota, Daisuke; Ohkuma, Masahisa; Iwaya, Takeshi; Nishida, Naohiro; Kogo, Ryunosuke; Sudo, Tomoya; Tanaka, Fumiaki; Shibata, Kohei; Toh, Hiroyuki; Sato, Tetsuya; F. Barnard, Graham; Fukagawa, Takeo; Yamamoto, Seiichiro; Nakanishi, Hayao; Sasaki, Shin; Miyano, Satoru; Watanabe, Toshiaki; Kuwano, Hiroyuki; Mimori, Koshi; Pantel, Klaus; Mori, Masaki

doi:10.1158/0008-5472.can-12-0326

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Plastin3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial–Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis

Shared by NobleBlocks on Apr 1, 2013 • 12:00 AM UTC

Authors:

Takehiko Yokobori

Hisae Iinuma

Teppei Shimamura

Abstract

Abstract Circulating tumor cells (CTC) in blood have attracted attention both as potential seeds for metastasis and as biomarkers. However, most CTC detection systems might miss epithelial–mesenchymal transition (EMT)-induced metastatic cells because detection is based on epithelial markers. First, ...

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