Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

K. Kolas, Nadine; Ross Chapman, J.; Nakada, Shinichiro; Ylanko, Jarkko; Chahwan, Richard; D. Sweeney, Frédéric; Panier, Stephanie; Mendez, Megan; Wildenhain, Jan; M. Thomson, Timothy; Pelletier, Laurence; P. Jackson, Stephen; Durocher, Daniel

doi:10.1126/science.1150034

Public

Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

Published in Science • Nov 16, 2007

Authors:

Nadine K. Kolas

J. Ross Chapman

Shinichiro Nakada

Abstract

Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage mediator protein MDC1, the p53-binding protein 1 (53BP1), and the breast cancer susceptibility protein BRCA1 to sites of damaged DNA. Here, we reveal that the ubiquitin ligase RNF8 mediates ubiquitin conjugation a...

Subject

DNA damage

Ubiquitin ligase

G2-M DNA damage checkpoint

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!