SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

Hou, Xiuyun; Xu, Shanqin; A. Maitland-Toolan, Karlene; Sato, Kaori; Jiang, Bingbing; Ido, Yasuo; Lan, Fan; Walsh, Kenneth; Wierzbicki, Michel; J. Verbeuren, Tony; A. Cohen, Richard; Zang, Mengwei

doi:10.1074/jbc.m802187200

Public

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

Published in Journal of Biological Chemistry • May 15, 2008

Authors:

Xiuyun Hou

Shanqin Xu

Karlene A. Maitland-Toolan

Abstract

Resveratrol may protect against metabolic disease through activating SIRT1 deacetylase. Because we have recently defined AMPK activation as a key mechanism for the beneficial effects of polyphenols on hepatic lipid accumulation, hyperlipidemia, and atherosclerosis in type 1 diabetic mice, we hypothe...

Subject

AMPK

AMP-activated protein kinase

Lipid metabolism

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