Phyllanthus amarus down‐regulates hepatitis B virus mRNA transcription and replication

Lee, Chia‐Za; Ott, Mélanie; Panchatcharam Thyagarajan, Sadras; A. Shafritz, David; D. Burk, Robert; Gupta, Sasha

doi:10.1046/j.1365-2362.1996.410595.x

Public

Phyllanthus amarus down‐regulates hepatitis B virus mRNA transcription and replication

Published in European Journal of Clinical Investigation • Dec 1, 1996

Authors:

Chia‐Za Lee

Mélanie Ott

Sadras Panchatcharam Thyagarajan

Abstract

The Phyllanthus amarus plant shows potential for treating hepatitis B virus. To define the mechanism of action of P. amarus, we used HepG2 2.2.15 cells, which support hepatitis B virus replication. P. amarus inhibited hepatitis B virus polymerase activity, decreased episomal hepatitis B virus DNA co...

Subject

Hepatitis B virus

Biology

Woodchuck hepatitis virus

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