Comprehensive mutational analysis of the <i>VHL</i> gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters

Kondo, Keiichi; Yao, Masahiro; Yoshida, Minoru; Kishida, Takeshi; Shuin, Taro; Miura, Takeshi; Moriyama, Masatoshi; Kobayashi, Kazuki; Sakai, Naoki; Kaneko, Shigeki; Kawakami, Satoshi; Baba, Masaya; Nakaigawa, Noboru; Nagashima, Yoji; Nakatani, Yukio; Hosaka, Masahiko

doi:10.1002/gcc.10054

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Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters

Published in Genes Chromosomes and Cancer • Feb 7, 2002

Authors:

Keiichi Kondo

Masahiro Yao

Minoru Yoshida

Abstract

To delineate more precisely the somatic von Hippel-Lindau disease (VHL) gene alteration as well as to elucidate its etiologic role in renal tumorigenesis, we examined a total of 240 sporadic renal cell carcinomas (RCCs) for somatic VHL gene alterations by DNA-SSCP followed by sequencing, methylation...

Subject

Biology

Loss of heterozygosity

Carcinogenesis

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