Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.

Geiger, Jörg; Nolte, Christiané; Butt, Elke; O. Sage, Stewart; Walter, Ulrich

doi:10.1073/pnas.89.3.1031

Public

Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.

Published in Proceedings of the National Academy of Sciences • Feb 1, 1992

Authors:

Jörg Geiger

Christiané Nolte

Elke Butt

Abstract

Most platelet agonists activate and elevate the cytosolic free calcium concentration in human platelets through receptor-dependent mechanisms that are antagonized by cAMP- and cGMP-elevating agents. Nitrovasodilators such as nitroprusside and endothelium-derived relaxing factor are potent cGMP-eleva...

Subject

Chemistry

Protein kinase A

cGMP-dependent protein kinase

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