ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin for Hepatitis C with Cirrhosis

Poordad, Fred; Hézode, Christophe; Trinh, Roger; V. Kowdley, Kris; Zeuzem, Stefan; Agarwal, Kosh; L. Shiffman, Mitchell; Wedemeyer, Heiner; Berg, Thomas; M. Yoshida, Eric; Forns, Xavier; Lovell, Sandra; Da Silva‐Tillmann, Barbara; A. Collins, Christine; Campbell, Andrew; Podsadecki, Thomas; Bernstein, Barry

doi:10.1056/nejmoa1402869

Public

ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin for Hepatitis C with Cirrhosis

Published in New England Journal of Medicine • Apr 12, 2014

Authors:

Fred Poordad

Christophe Hézode

Roger Trinh

Abstract

BACKGROUND: Interferon-containing regimens for the treatment of hepatitis C virus (HCV) infection are associated with increased toxic effects in patients who also have cirrhosis. We evaluated the interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r), the NS5A inhib...

Subject

Ombitasvir

Dasabuvir

Ribavirin

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