Effects of indomethacin and meclofenamate on renin release and renal hemodynamic function during chronic sodium depletion in conscious dogs.

M De Forrest, J; O. Davis, James; H. Freeman, Ronald; A. Seymour, Andrea; P. Rowe, Brian; Williams, Gail; P. Davis, Thomas

doi:10.1161/01.res.47.1.99

Public

Effects of indomethacin and meclofenamate on renin release and renal hemodynamic function during chronic sodium depletion in conscious dogs.

Published in Circulation Research • Jul 1, 1980

Authors:

J M De Forrest

James O. Davis

Ronald H. Freeman

Abstract

We studied the control of renin release and renal hemodynamic function by administering prostaglandin synthetase inhibitors to conscious sodium-depleted dogs with blockade of the adrenergic nervous system induced by bilateral renal denervation and propranolol administration. Indomethacin (10 mg/kg) ...

Subject

Macula densa

Plasma renin activity

Endocrinology

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