Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

Stokoe, David; R. Stephens, Leonard; Copeland, Terry; R. J. Gaffney, Piers; B. Reese, Colin; F. Painter, Gavin; B. Holmes, Andrew; McCormick, Frank; T. Hawkins, Phillip

doi:10.1126/science.277.5325.567

Public

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

Published in Science • Jul 25, 1997

Authors:

David Stokoe

Leonard R. Stephens

Terry Copeland

Abstract

Protein kinase B (PKB) is a proto-oncogene that is activated in signaling pathways initiated by phosphoinositide 3-kinase. Chromatographic separation of brain cytosol revealed a kinase activity that phosphorylated and activated PKB only in the presence of phosphatidylinositol-3,4,5-trisphosphate [Pt...

Subject

Pleckstrin homology domain

Phosphatidylinositol

Protein kinase B

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