The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis.

S Lohmander, L; J Neame, P; D Sandy, J

doi:10.1002/art.1780360906

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The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis.

Shared by NobleBlocks on Sep 1, 1993 • 12:00 AM UTC

Authors:

L S Lohmander

P J Neame

J D Sandy

Abstract

OBJECTIVE: To determine the proteolytic fragmentation patterns and N-terminal sequence of aggrecan fragments in human synovial fluid from patients with inflammatory arthritides, joint injury, or osteoarthritis (OA). METHODS: Knee synovial fluid was obtained from patients with joint injury, OA, acute...

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