The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

Lohmander, Stefan; J. Neame, Peter; D. Sandy, John

doi:10.1002/art.1780360906

Public

The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

Published in Arthritis & Rheumatism • Sep 1, 1993

Authors:

Stefan Lohmander

Peter J. Neame

John D. Sandy

Abstract

OBJECTIVE: To determine the proteolytic fragmentation patterns and N-terminal sequence of aggrecan fragments in human synovial fluid from patients with inflammatory arthritides, joint injury, or osteoarthritis (OA). METHODS: Knee synovial fluid was obtained from patients with joint injury, OA, acute...

Subject

Aggrecanase

Aggrecan

Synovial fluid

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