Compensatory Changes in the Noradrenergic Nervous System in the Locus Ceruleus and Hippocampus of Postmortem Subjects with Alzheimer's Disease and Dementia with Lewy Bodies

Szot, Patricia; S. White, Sylvia; Lynne Greenup, J.; B. Leverenz, James; R. Peskind, Elaine; A. Raskind, Murray

doi:10.1523/jneurosci.4265-05.2006

Public

Compensatory Changes in the Noradrenergic Nervous System in the Locus Ceruleus and Hippocampus of Postmortem Subjects with Alzheimer's Disease and Dementia with Lewy Bodies

Published in Journal of Neuroscience • Jan 11, 2006

Authors:

Patricia Szot

Sylvia S. White

J. Lynne Greenup

Abstract

In Alzheimer's disease (AD), there is a significant loss of locus ceruleus (LC) noradrenergic neurons. However, functional and anatomical evidence indicates that the remaining noradrenergic neurons may be compensating for the loss. Because the noradrenergic system plays an important role in learning...

Subject

Locus Ceruleus

Dementia

Hippocampus

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