Addition of Sodium Bicarbonate to Lidocaine Decreases the Duration of Peripheral Nerve Block in the Rat

J. Sinnott, Catherine; M. Garfield, Joseph; G. Thalhammer, Johannes; R. Strichartz, Gary

doi:10.1097/00000542-200010000-00028

Public

Addition of Sodium Bicarbonate to Lidocaine Decreases the Duration of Peripheral Nerve Block in the Rat

Published in Anesthesiology • Oct 1, 2000

Authors:

Catherine J. Sinnott

Joseph M. Garfield

Johannes G. Thalhammer

Abstract

BACKGROUND: Adding sodium bicarbonate to lidocaine to enhance its efficacy during peripheral nerve block is controversial. The authors studied the effect of adding sodium bicarbonate to lidocaine with and without epinephrine versus equivalent alkalinization by sodium hydroxide (NaOH) on onset, degre...

Subject

Lidocaine

Sodium bicarbonate

Epinephrine

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