Chronic depolarization enhances the trophic effects of brain‐derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss

K. Shepherd, Robert; Coco, Anne; B. Epp, Stephanie; M. Crook, Jeremy

doi:10.1002/cne.20564

Public

Chronic depolarization enhances the trophic effects of brain‐derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss

Published in The Journal of Comparative Neurology • Apr 20, 2005

Authors:

Robert K. Shepherd

Anne Coco

Stephanie B. Epp

Abstract

The development and maintenance of spiral ganglion neurons (SGNs) appears to be supported by both neural activity and neurotrophins. Removal of this support leads to their gradual degeneration. Here, we examined whether the exogenous delivery of the neurotrophin brain-derived neurotrophic factor (BD...

Subject

Spiral ganglion

Neurotrophic factors

Cochlea

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