Thalidomide for the Treatment of Oral Aphthous Ulcers in Patients with Human Immunodeficiency Virus Infection

M. Jacobson, Jeffrey; S. Greenspan, John; Spritzler, John; Ketter, Nzeera; L. Fahey, John; Brooks Jackson, J.; K. Fox, Lawrence; Chernoff, Miriam; W. Wu, Albert; A. MacPhail, Laurie; J. Vasquez, Guillermo; A. Wohl, David

doi:10.1056/nejm199705223362103

Public

Thalidomide for the Treatment of Oral Aphthous Ulcers in Patients with Human Immunodeficiency Virus Infection

Published in New England Journal of Medicine • May 22, 1997

Authors:

Jeffrey M. Jacobson

John S. Greenspan

John Spritzler

Abstract

BACKGROUND: In patients with advanced human immunodeficiency virus (HIV) infection, aphthous ulceration of the mouth and oropharynx can become extensive and debilitating. Preliminary reports suggest that thalidomide may promote the healing of oral aphthous ulcers. METHODS: We performed a double-blin...

Subject

Medicine

Thalidomide

Placebo

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