Oxidized Low Density Lipoprotein Inhibits Interleukin-12 Production in Lipopolysaccharide-activated Mouse Macrophages via Direct Interactions between Peroxisome Proliferator-activated Receptor-γ and Nuclear Factor-κB

Wol Chung, Su; Yun Kang, Bok; Hyun Kim, Seung; Kim Pak, Youngmi; Cho, Daeho; Trinchieri, Giorgio; Sung Kim, Tae

doi:10.1074/jbc.m002577200

Public

Oxidized Low Density Lipoprotein Inhibits Interleukin-12 Production in Lipopolysaccharide-activated Mouse Macrophages via Direct Interactions between Peroxisome Proliferator-activated Receptor-γ and Nuclear Factor-κB

Published in Journal of Biological Chemistry • Oct 1, 2000

Authors:

Su Wol Chung

Bok Yun Kang

Seung Hyun Kim

Abstract

Lipopolysaccharide (LPS) increases the production of interleukin-12 (IL-12) from mouse macrophages via a kappaB site within the IL-12 p40 promoter. In this study, we found that oxidized low density lipoprotein (oxLDL) inhibited this LPS-stimulated production of IL-12 in a dose-dependent manner while...

Subject

Transactivation

Lipopolysaccharide

Molecular biology

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