A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects.

H Rex, John; G Pappas, Peter; W Karchmer, Adolf; Sobel, Jack; E Edwards, John; Hadley, Susan; Brass, Corstiaan; A Vazquez, Jose; W Chapman, Stanley; W Horowitz, Harold; Zervos, Marcus; McKinsey, David; Lee, Jeannette; Babinchak, Timothy; W Bradsher, Robert; D Cleary, John; M Cohen, David; Danziger, Larry; Goldman, Mitchell; Goodman, Jesse; Hilton, Eileen; E Hyslop, Newton; H Kett, Daniel; Lutz, Jon; H Rubin, Robert; Michael Scheld, W; Schuster, Mindy; Simmons, Bryan; K Stein, David; G Washburn, Ronald; Mautner, Linda; Chu, Teng-Chiao; Panzer, Helene; B Rosenstein, Rebecca; Booth, Jenia; Institute of Allergy and Infectious Diseases Mycoses Study Group, National

doi:10.1086/374850

Public

A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects.

Shared by NobleBlocks on May 15, 2003 • 12:00 AM UTC

Authors:

John H Rex

Peter G Pappas

Adolf W Karchmer

Abstract

A randomized, blinded, multicenter trial was conducted to compare fluconazole (800 mg per day) plus placebo with fluconazole plus amphotericin B (AmB) deoxycholate (0.7 mg/kg per day, with the placebo/AmB component given only for the first 5-6 days) as therapy for candidemia due to species other tha...

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