Frequent Mutations of Chromatin Remodeling Gene <i>ARID1A</i> in Ovarian Clear Cell Carcinoma

Jones, Siân; Wang, Tian‐Li; Shih, Ie‐Ming; Mao, Tsui-Lien; Nakayama, Kentaro; B.S. Roden, Richard; Glas, Ruth; J. Slamon, Dennis; A. Díaz, Luis; Vogelstein, Bert; W. Kinzler, Kenneth; E. Velculescu, Victor; Papadopoulos, Nickolas

doi:10.1126/science.1196333

Public

Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

Published in Science • Sep 8, 2010

Authors:

Siân Jones

Tian‐Li Wang

Ie‐Ming Shih

Abstract

Ovarian clear cell carcinoma (OCCC) is an aggressive human cancer that is generally resistant to therapy. To explore the genetic origin of OCCC, we determined the exomic sequences of eight tumors after immunoaffinity purification of cancer cells. Through comparative analyses of normal cells from the...

Subject

ARID1A

Chromatin remodeling

Biology

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