Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

Gire, Stephen; Goba, Augustine; G. Andersen, Kristian; Sealfon, Rachel; J. Park, Daniel; Kanneh, Lansana; Jalloh, Simbirie; Momoh, Mambu; Fullah, Mohamed; Dudas, Gytis; Wohl, Shirlee; Moses, Lina; L. Yozwiak, Nathan; Winnicki, S; B. Matranga, Christian; M. Malboeuf, Christine; Qu, James; D. Gladden, Adrianne; F. Schaffner, S.; Yang, Xiao; Jiang, Panpan; Nekoui, Mahan; Colubri, Andrés; Coomber, Moinya; Fonnie, Mbalu; Moigboi, Alex; Gbakie, Michael; Kamara, Fatima; Tucker, Veronica; Konuwa, Edwin; Saffa, Sidiki; Sellu, Josephine; A. Jalloh, Abdul; Kovoma, Alice; Koninga, James; Mustapha, Ibrahim; Kargbo, Kandeh; Foday, Momoh; Yillah, Mohamed; Kanneh, Franklyn; Robert, Willie; L.B. Massally, James; B. Chapman, Sinéad; Bochicchio, James; I. Murphy, Cheryl; Nusbaum, Chad; Young, Sarah; J. Birren, Susan; S. Grant, Donald; S. Scheiffelin, John; S. Lander, Eric; Happi, Christian; M. Gevao, Sahr; Gnirke, Andreas; Rambaut, Andrew; F. Garry, Robert; Humarr Khan, Sheik; C. Sabeti, Pardis

doi:10.1126/science.1259657

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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

Published in Science • Aug 29, 2014

Authors:

Stephen Gire

Augustine Goba

Kristian G. Andersen

Abstract

In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000× coverage. We observed a rapid accumulation of interhost and intrahost genetic variation, allowing us to charact...

Subject

Sierra leone

Ebola virus

Outbreak

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