Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis.

E, Nandrot; EM, Dufour; AC, Provost; MO, Péquignot; S, Bonnel; K, Gogat; D, Marchant; C, Rouillac; de Condé B, Sépulchre; MT, Bihoreau; C, Shaver; JL, Dufier; C, Marsac; M, Lathrop; M, Menasche; MM, Abitbol

doi:10.1006/nbdi.2000.0328

Public

Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis.

Shared by NobleBlocks on Dec 1, 2000 • 12:00 AM UTC

Authors:

Nandrot E

Dufour EM

Provost AC

Abstract

The RCS rat presents an autosomal recessive retinal pigment epithelium dystrophy characterized by the outer segments of photoreceptors being phagocytosis-deficient. A systematic genetic study allowed us to restrict the interval containing the rdy locus to that between the markers D3Mit13 and D3Rat25...

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