53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection

Zimmermann, Michal; Lottersberger, Francisca; B.C. Buonomo, Sara; Sfeir, Agnel; de Lange, Titia

doi:10.1126/science.1231573

Public

53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection

Published in Science • Jan 11, 2013

Authors:

Michal Zimmermann

Francisca Lottersberger

Sara B.C. Buonomo

Abstract

The choice between double-strand break (DSB) repair by either homology-directed repair (HDR) or nonhomologous end joining (NHEJ) is tightly regulated. Defects in this regulation can induce genome instability and cancer. 53BP1 is critical for the control of DSB repair, promoting NHEJ, and inhibiting ...

Subject

Telomere

DNA repair

DNA

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!