Pyrazinamide Inhibits Trans-Translation in <i>Mycobacterium tuberculosis</i>

Shi, Wanliang; Zhang, Xuelian; Jiang, Xin; Yuan, Haiming; Seok Lee, Jong; E. Barry, Clifton; Wang, Honghai; Zhang, Wenhong; Zhang, Ying

doi:10.1126/science.1208813

Public

Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis

Published in Science • Aug 12, 2011

Authors:

Wanliang Shi

Xuelian Zhang

Xin Jiang

Abstract

Pyrazinamide (PZA) is a first-line tuberculosis drug that plays a unique role in shortening the duration of tuberculosis chemotherapy. PZA is hydrolyzed intracellularly to pyrazinoic acid (POA) by pyrazinamidase (PZase, encoded by pncA), an enzyme frequently lost in PZA-resistant strains, but the ta...

Subject

Pyrazinamide

Mycobacterium tuberculosis

Tuberculosis

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