A Role for Endoglin in Coupling eNOS Activity and Regulating Vascular Tone Revealed in Hereditary Hemorrhagic Telangiectasia

Toporsian, Mourad; Gros, Robert; G. Kabir, Mohammed; Vera, Sonia; Govindaraju, Karuthapillai; H. Eidelman, David; Husain, Mansoor; Letarte, Michelle

doi:10.1161/01.res.0000159936.38601.22

Public

A Role for Endoglin in Coupling eNOS Activity and Regulating Vascular Tone Revealed in Hereditary Hemorrhagic Telangiectasia

Published in Circulation Research • Feb 18, 2005

Authors:

Mourad Toporsian

Robert Gros

Mohammed G. Kabir

Abstract

Decreased endothelial NO synthase (eNOS)-derived NO bioavailability and impaired vasomotor control are crucial factors in cardiovascular disease pathogenesis. Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a vascular disorder associated with ENDOGLIN (ENG) haploinsufficiency and characterize...

Subject

Enos

Endoglin

Internal medicine

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