Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

C. Sanguinetti, Michael; K. Jurkiewicz, Nancy

doi:10.1085/jgp.96.1.195

Public

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

Published in The Journal of General Physiology • Jul 1, 1990

Authors:

Michael C. Sanguinetti

Nancy K. Jurkiewicz

Abstract

An envelope of tails test was used to show that the delayed rectifier K+ current (IK) of guinea pig ventricular myocytes results from the activation of two outward K+ currents. One current was specifically blocked by the benzenesulfonamide antiarrhythmic agent, E-4031 (IC50 = 397 nM). The drug-sensi...

Subject

Chemistry

Membrane potential

Sotalol

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