Prevalence, Characteristics, and Publication of Discontinued Randomized Trials

Kasenda, Benjamin; von Elm, Erik; J. You, John; Blümle, Anette; Tomonaga, Yuki; Saccilotto, Ramon; Amstutz, Alain; Bengough, Theresa; J Meerpohl, Joerg; Stegert, Mihaela; A.O. Tikkinen, Kari; Neumann, Ignacio; Carrasco‐Labra, Alonso; Faulhaber, Markus; Mulla, Sohail; Mertz, Dominik; A. Akl, Elie; Bassler, Dirk; W. Busse, Jason; Ferreira‐González, Ignacio; Lamontagne, François; Nordmann, Alain; Gloy, Viktoria; Raatz, Heike; Moja, Lorenzo; Rosenthal, Rachel; Ebrahim, Shanil; Schandelmaier, Stefan; Xin, Sun; Olav Vandvik, Per; C. Johnston, Bradley; A. Walter, Martin; Burnand, Bernard; Schwenkglenks, Matthias; G. Hemkens, Lars; C. Bucher, Heiner; Guyatt, Gordon; Briel, Matthias

doi:10.1001/jama.2014.1361

Public

Prevalence, Characteristics, and Publication of Discontinued Randomized Trials

Published in JAMA • Mar 11, 2014

Authors:

Benjamin Kasenda

Erik von Elm

John J. You

Abstract

IMPORTANCE: The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. The epidemiology of discontinued RCTs, however, remains unclear. OBJECTIVES: To determine the prevalence, characteristics, and publication history of discontinued ...

Subject

Medicine

Discontinuation

Randomized controlled trial

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