Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-α-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial

Van Nieuwenhove, Simon; J. Schechter, Paul; Declercq, J.; Boné, Georges; Burke, JM; Sjoerdsma, Albert

doi:10.1016/0035-9203(85)90195-6

Public

Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-α-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial

Published in Transactions of the Royal Society of Tropical Medicine and Hygiene • Jan 1, 1985

Authors:

Simon Van Nieuwenhove

Paul J. Schechter

J. Declercq

Abstract

Difluoromethylornithine (DFMO), a specific, irreversible inhibitor of polyamine biosynthesis shown to be curative in animal models inoculated with various Trypanosoma spp., was evaluated in the Southern Sudan in a preliminary open clinical field trial in patients infected with Trypanosoma brucei gam...

Subject

Eflornithine

Medicine

Regimen

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