Spinal cord degeneration in C57BL/6N mice following induction of experimental parkinsonism with MPTP

Samantaray, Supriti; H. Knaryan, Varduhi; T. Butler, Jonathan; K. Ray, Swapan; L. Banik, Naren

doi:10.1111/j.1471-4159.2007.05091.x

Public

Spinal cord degeneration in C57BL/6N mice following induction of experimental parkinsonism with MPTP

Published in Journal of Neurochemistry • Oct 24, 2007

Authors:

Supriti Samantaray

Varduhi H. Knaryan

Jonathan T. Butler

Abstract

We examined neurodegeneration in spinal cord (SC) and role of such extra-nigral degeneration in MPTP-induced experimental parkinsonism in C57BL/6N mice. HPLC-photodiode array analysis confirmed presence of the active neurotoxin MPP+ in SC after single injection of MPTP (25 mg/kg, i.p.). Mitochondria...

Subject

MPTP

Neurotoxin

Parkinsonism

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