Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

M. Brainard, Diana; Seung, Edward; Frahm, Nicole; Cariappa, Annaiah; C. Bailey, Charles; K. Hart, William; Shin, Hae-Sook; F. Brooks, Sarah; L. Knight, Heather; Eichbaum, Quentin; Yang, Yong-Guang; Sykes, Megan; D. Walker, Bruce; J. Freeman, Gordon; Pillai, Shiv; V. Westmoreland, Susan; Brander, Christian; D. Luster, Andrew; M. Tager, Andrew

doi:10.1128/jvi.02207-08

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Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

Shared by NobleBlocks on Jul 15, 2009 • 12:00 AM UTC

Authors:

Diana M. Brainard

Edward Seung

Nicole Frahm

Abstract

ABSTRACT The generation of humanized BLT mice by the cotransplantation of human fetal thymus and liver tissues and CD34 + fetal liver cells into nonobese diabetic/severe combined immunodeficiency mice allows for the long-term reconstitution of a functional human immune system, with human T cells, B ...

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