Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

M. Brainard, Diana; Seung, Edward; Frahm, Nicole; Cariappa, Annaiah; C. Bailey, Charles; K. Hart, William; Shin, Hae‐Sook; F. Brooks, Sarah; Knight, Heather; Eichbaum, Quentin; Yang, Yong‐Guang; Sykes, Megan; D. Walker, Bruce; J. Freeman, Gordon; Pillai, Shiv; V. Westmoreland, Susan; Brander, Christian; D. Luster, Andrew; M. Tager, Andrew

doi:10.1128/jvi.02207-08

Public

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

Published in Journal of Virology • May 6, 2009

Authors:

Diana M. Brainard

Edward Seung

Nicole Frahm

Abstract

The generation of humanized BLT mice by the cotransplantation of human fetal thymus and liver tissues and CD34(+) fetal liver cells into nonobese diabetic/severe combined immunodeficiency mice allows for the long-term reconstitution of a functional human immune system, with human T cells, B cells, d...

Subject

Humanized mouse

Immune system

Biology

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