Benzothiazinones Kill <i>Mycobacterium tuberculosis</i> by Blocking Arabinan Synthesis

Makarov, Vadim; Manina, Giulia; Mikušová, Katarı́na; Möllmann, Ute; B. Ryabova, O.; Saint‐Joanis, Brigitte; Dhar, Neeraj; Rosalia Pasca, Maria; Buroni, Silvia; Lucarelli, Anna; Milano, Anna; De Rossi, Edda; Beláňová, Martina; Bobovská, Adela; Dianišková, Petronela; Korduláková, Jana; Sala, Claudia; Fullam, Elizabeth; Schneider, Patricia; D. McKinney, John; Brodin, Priscille; Christophe, Thierry; J. Waddell, Simon; D. Butcher, Philip; Albrethsen, Jakob; Rosenkrands, Ida; Brosch, Roland; Nandi, Vrinda; Bharath, Sowmya; Gaonkar, Sheshagiri; Krishan Shandil, Radha; Balasubramanian, V.; S. Balganesh, Tanjore; Tyagi, Sandeep; Grosset, J; Riccardi, Giovanna; T. Cole, Stewart

doi:10.1126/science.1171583

Public

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

Published in Science • Mar 19, 2009

Authors:

Vadim Makarov

Giulia Manina

Katarı́na Mikušová

Abstract

New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB. Using genetics and bioc...

Subject

Ethambutol

Mycobacterium tuberculosis

Tuberculosis

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