Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation

Fu, Yue; Wang, Yan; Du, Liqing; Xu, Chang; Cao, Jia; Fan, Ti-Qiang; Liu, Jianxiang; Xu, Su; Fan, Saijun; Liu, Qiang; Fan, Feiyue

doi:10.3390/ijms140714105

Public

Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation

Published in International Journal of Molecular Sciences • Jul 8, 2013

Authors:

Yue Fu

Yan Wang

Liqing Du

Abstract

IL-1β, a pro-inflammatory cytokine, has been shown to contribute to radiation injury. Sirt1, an NAD+-dependent class III protein deacetylase, plays an important role in the regulation of the proinflammatory cytokines involved in inflammation-associated diseases. The relationship between Sirt1 and IL...

Subject

Resveratrol

Sirtuin 1

Proinflammatory cytokine

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