Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial

Akhondzadeh, Shahin; Jafari, Sara; Raisi, Firoozeh; Ali Nasehi, Abbas; Ghoreishi, Aboulfazl; Salehi, Bahman; Mohebbi-Rasa, Soodeh; Raznahan, Maedeh; Kamalipour, Abbas

doi:10.1002/da.20589

Public

Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial

Published in Depression and Anxiety • Jun 3, 2009

Authors:

Shahin Akhondzadeh

Sara Jafari

Firoozeh Raisi

Abstract

BACKGROUND: The pathophysiology of depression is associated with the hyperactivity of immune inflammatory responses. Cyclooxygenase-2 inhibitors such as celecoxib reduce the production of pro-inflammatory cytokines. The purpose of the present investigation was to assess the efficacy of celecoxib as ...

Subject

Celecoxib

Depression (economics)

Placebo

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